EEG spectra following phenytoin infusion in seizure patients

Diphenylhydantoin (DPH) kinetics were studied in five male patients with poorly controlled seizures. EEG recordings were taken on four of the patients immediately prior to and 30 minutes following a 60 minute i.v. infusion of phenytoin sodium. Mean phenytoin levels following post-infusion EEG recordings were 17.1 mg/L. Spectral analysis revealed that phenytoin produced a decrease in the variance of EEG spectral power as a function of time in frequencies between 8-18 Hz. This decrease in the variance of the time series of EEG spectra suggests increased EEG stability and may represent an electrographic marker of the anticonvulsant action of phenytoin.