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Related Experiment Videos

Contrast agent-induced emesis.

A R Manhire, P Dawson, R Dennet

    Clinical Radiology
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Sodium meglumine ioxaglate (Hexabrix) causes significant nausea and vomiting during central venous injections for angiography, unlike iohexol (Omnipaque). This suggests ioxaglate

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    Area of Science:

    • Radiology and Diagnostic Imaging
    • Pharmacology
    • Clinical Trials

    Background:

    • Central venous injections are crucial for diagnostic imaging procedures like digital subtraction angiography.
    • Contrast media selection can impact patient experience and safety.
    • Previous studies have not fully elucidated the gastrointestinal side effects of specific contrast agents.

    Purpose of the Study:

    • To compare the incidence of nausea and vomiting between sodium meglumine ioxaglate (Hexabrix) and iohexol (Omnipaque) during central venous injections for digital subtraction angiography.
    • To investigate potential mechanisms for observed side effects.

    Main Methods:

    • A comparative study involving 101 patients undergoing central venous injections for digital subtraction angiography.
    • Patients received either sodium meglumine ioxaglate (Hexabrix) or iohexol (Omnipaque).

    Related Experiment Videos

  • Incidence of nausea and vomiting was recorded and compared between the two groups.

    • Main Results:

    • Sodium meglumine ioxaglate (Hexabrix) was associated with a 24.5% incidence of nausea and vomiting.
    • Iohexol (Omnipaque) showed a 0% incidence of these side effects.
    • A statistically significant difference in the occurrence of nausea and vomiting was observed between the two contrast agents.

    Conclusions:

    • Sodium meglumine ioxaglate (Hexabrix) is linked to a higher incidence of nausea and vomiting compared to iohexol (Omnipaque) in this patient cohort.
    • The anticholinesterase activity of ioxaglate is proposed as a potential mechanism for these adverse gastrointestinal effects.
    • Clinicians should consider these findings when selecting contrast media for angiography to optimize patient comfort and safety.