Contrast agent-induced emesis

When used in central venous injections for digital subtraction angiography, sodium meglumine ioxaglate (Hexabrix) has been found to be associated with a high incidence of nausea and vomiting (24.5%), when compared with iohexol (Omnipaque) (0%) in 101 patients. A mechanism is suggested to account for this observation based on the anticholinesterase activity of ioxaglate.