The cyclic motor activity of the ovine gut: its reset at a faster rhythm

In adult sheep, the frequency of the migrating motor complexes (MMC) was increased by the duodenal administration of methysergide, but not affected by other 5-HT1 or 5-HT2 antagonists. This reset of the MMC pattern at a faster rhythm suggests a selective action on the enteric neuronal serotoninergic mechanism modulating the pacing of the gut cyclic motor activity.