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Solitary primary intracranial extracerebral glioma. Case report
Abstract:
A case is presented of a solitary primary extracerebral mixed glioma occurring in the right suprasellar and parasellar region of a 49-year-old woman who had bilateral temporal hemianopsia for 3 months. At craniotomy, the well demarcated outline and extracerebral location of the tumor suggested that it was a meningioma. However, its gliomatous nature was confirmed by identification of glial fibrillary acidic protein (GFAP) in the tumor cells. Review of nine reported solitary primary intracranial extracerebral gliomas, including the present case, revealed that they tended to occur in the third to fifth decades of life, in patients with an average age of 42 1/2 years, and without sexual predilection. All were supratentorial with a tendency to be situated in the vicinity of the Sylvian fissure. Only the glioma in the present case was at the cranial base. They were diagnosed as three astrocytomas, two glioblastomas, two oligodendrogliomas, one astroblastoma, and one mixed glioma. A suggestion is made that all these gliomas arose primarily from heterotopic neuroglia in the leptomeninges.
Insights
This study presents a rare extracerebral mixed glioma case. Such gliomas, often misdiagnosed as meningiomas, may originate from heterotopic neuroglia in the leptomeninges.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Solitary primary extracerebral gliomas are rare intracranial neoplasms.
- Distinguishing them from meningiomas can be challenging due to location and presentation.
Observation:
- A case of a solitary primary extracerebral mixed glioma in the suprasellar/parasellar region is detailed.
- The tumor, initially suspected as a meningioma, was confirmed as gliomatous by glial fibrillary acidic protein (GFAP) identification.
Findings:
- A review of ten such cases (including this one) shows a predilection for the third to fifth decades of life (average age 42.5 years) with no sexual preference.
- Most tumors are supratentorial, near the Sylvian fissure; this case involved the cranial base.
- Histological subtypes include astrocytomas, glioblastomas, oligodendrogliomas, astroblastoma, and mixed gliomas.
Implications:
- The findings suggest these gliomas may arise from heterotopic neuroglia within the leptomeninges.
- Accurate diagnosis is crucial for appropriate management and understanding of glioma origins.