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Related Experiment Videos

[Kidney function during radiosensitization with metronidazole].

A M D'iakova, N V Stefani, V G Andreev

    Meditsinskaia Radiologiia
    |August 1, 1984
    PubMed
    Summary

    Radiation therapy for laryngeal cancer, with or without metronidazole, may impair kidney function. Studies show changes in kidney function markers persist even after treatment cessation.

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    [The results of combined treatment of patients with locally advanced laryngeal cancer using preoperative chemoradiotherapy].

    Voprosy onkologii·2016

    Area of Science:

    • Nephrology
    • Oncology
    • Radiology

    Context:

    • Laryngeal cancer patients undergoing radiation therapy.
    • Mean fractionation with metronidazole radiosensitization up to 20 Gy.
    • Follow-up radiation therapy up to 32 Gy without radiosensitizer.

    Purpose:

    • To evaluate renal function changes during and after radiation therapy for laryngeal cancer.
    • To investigate the potential renal toxicity of metronidazole as a radiosensitizer.

    Summary:

    • Radiation therapy for laryngeal cancer, particularly with metronidazole, altered plasma levels of residual nitrogen, urea, and uric acid, while decreasing creatinine.
    • Renal function indicators like urea clearance and Ambard's urosecretory constant showed negative shifts.
    • These renal function alterations persisted post-treatment, suggesting a potential direct nephrotoxic effect of metronidazole independent of oxygenation status.

    Impact:

    • Highlights potential renal side effects of laryngeal cancer radiation therapy.
    • Suggests metronidazole may have direct renal toxicity, warranting further investigation.
    • Informs clinical monitoring of kidney function in cancer patients receiving radiation and radiosensitizers.

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