Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immune complexes in pre-eclampsia.

G M Stirrat, C W Redman, R J Levinsky

    British Medical Journal
    |June 3, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia.

    Journal of reproductive immunology·2018
    Same author

    Angiogenic factors: potential to change clinical practice in pre-eclampsia?

    BJOG : an international journal of obstetrics and gynaecology·2017
    Same author

    Trophoblast Glycoprotein (TPGB/5T4) in Human Placenta: Expression, Regulation, and Presence in Extracellular Microvesicles and Exosomes.

    Reproductive sciences (Thousand Oaks, Calif.)·2017
    Same author

    Pre-eclampsia: Definitions, paternal contributions and a four stage model.

    Pregnancy hypertension·2015
    Same author

    OS100. Plasma placental growth factor (PLGF) measurement in women presenting with suspected pre-eclampsia: the pelican study.

    Pregnancy hypertension·2015
    Same author

    Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis.

    Methods (San Diego, Calif.)·2015
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Women with severe pre-eclampsia show elevated levels of immune complexes, specifically IgG-containing and C1q-binding types. These findings suggest a potential role for immune complexes in pre-eclampsia pathogenesis.

    Area of Science:

    • Immunology
    • Obstetrics
    • Pathophysiology

    Background:

    • Immune complexes are implicated in various inflammatory conditions.
    • Understanding their role in pregnancy is crucial for maternal and fetal health.

    Purpose of the Study:

    • To investigate the presence and characteristics of circulating soluble immune complexes in severe pre-eclampsia.
    • To compare immune complex levels between pre-eclamptic and normal pregnancies.

    Main Methods:

    • Quantification of IgG-containing and C1q-binding immune complexes.
    • Comparison of levels in 16 severe pre-eclampsia patients versus 16 matched normal pregnancies.

    Main Results:

    • Patients with severe pre-eclampsia exhibited significantly higher levels of IgG-containing and C1q-binding immune complexes.

    Related Experiment Videos

  • Elevated immune complex levels were also observed in a small subset of normal pregnancies.

    • Conclusions:

    • Circulating immune complexes may contribute to the pathophysiology of severe pre-eclampsia.
    • Further research is needed to elucidate the diverse roles of immune complexes in normal and pre-eclamptic pregnancies.