[Ultrastructure of the peripheral blood lymphocytes in children with diabetes mellitus]

Electron microscopic changes occurring in peripheral blood lymphocytes of diabetes mellitus children are described. In the disease of medium severity, the protein-synthesizing apparatus volume in the blood cells decreases. Destabilization and loosening of plasmic and organoid membranes of agranulocytes are seen. In several cases subcellular reconstruction is combined with a profound destruction of mitochondrial membrane components and reticular cytoplasmic elements. The children with severe diabetes mellitus manifest pronounced alterations in lymphocytes. This disease pattern is marked by the involvement of both the ultrastructural components of the cytoplasm and the cellular nuclear apparatus, indicating stable inhibition of blood lymphocyte function. As a of multiple modality treatment the processes of intracellular reparative regeneration are activated, however the status of the blood lymphocyte membranes does not completely return to normal.