Related Experiment Video

Updated: Aug 17, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Reduced erythrocyte deformability and hyperfibrinogenemia in Nigerian diabetics with hemoglobin genotype HbAA

H L Reid, G O Obi, J M Oli

    Acta Diabetologica Latina
    |April 1, 1984
    PubMed

    Erythrocyte deformability (Vrbc) and plasma fibrinogen values were studied in 44 Nigerian diabetics and 41 age-matched controls, some of whom were hypertensives. All had normal hemoglobin genotype (HbAA). Vrbc was significantly reduced in the diabetic patients compared to the control group (p less than 0.005). Similarly, the Vrbc in hypertensive diabetics was significantly reduced below that in both non-hypertensive diabetics (p less than 0.01) and hypertensive controls (p less than 0.01). Plasma fibrinogen concentration was significantly raised in the diabetics compared to controls (p less than 0.01). Although the fibrinogen was higher in the hypertensive diabetics than in diabetics without hypertension the difference was not statistically significant. There was no significant difference between hypertensive controls and hypertensive diabetics even though the latter had a higher mean fibrinogen than controls without hypertension. We conclude that Nigerian diabetics with normal hemoglobin genotype, HbAA, have poorly deformable RBCs and a hyperfibrinogenemic plasma compared to a non-diabetic control group. These findings may have a considerable prognostic significance in terms of the patients' subsequent progress.

    More Related Videos

    Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry09:12

    Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

    Published on: January 12, 2018

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

    Published on: November 5, 2019

    Related Concept Videos

    Hemoglobin01:24

    Hemoglobin

    Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
    When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
    Disorders of Erythrocytes01:27

    Disorders of Erythrocytes

    Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
    Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
    A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
    On the other...
    Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

    Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

    Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
    Hyperglycemia01:29

    Hyperglycemia

    Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
    Diabetic Retinopathy01:27

    Diabetic Retinopathy

    DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...