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Related Experiment Videos

Neuronal blockade with morphine. A hypothesis.

R Sanchez, H Nielsen, L Heslet

    Anaesthesia
    |August 1, 1984
    PubMed
    Summary
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    A brachial plexus block with morphine provided significant pain relief for a patient with Pancoast's tumour. This novel approach offered 36 hours of analgesia, suggesting a potential new method for managing intractable cancer pain.

    Area of Science:

    • Oncology
    • Pain Medicine
    • Neurology

    Background:

    • Pancoast's tumours can cause severe, intractable pain due to brachial plexus invasion.
    • Standard opioid analgesia, such as subcutaneous morphine, may be insufficient for such pain.

    Observation:

    • A patient with a Pancoast tumour experienced unbearable pain despite receiving 180 mg of morphine subcutaneously daily.
    • An interscalene brachial plexus block was administered using 5 mg of morphine hydrochloride in 10 ml of saline.

    Findings:

    • Complete pain relief (analgesia) was achieved within 20 minutes post-block.
    • The analgesic effect persisted for 36 hours.

    Implications:

    • Local brachial plexus blockade with morphine may be an effective strategy for managing severe cancer-related neuropathic pain.

    Related Experiment Videos

  • The mechanism might involve neuro-axonal transport of morphine to the spinal cord.
  • Further controlled trials are warranted to validate this therapeutic approach.