Effect of beta-aminopropionitrile (BAPN) on corneal wound strength

BAPN (beta-aminopropionitrile), a known inhibitor of collagen cross-linking, was instilled topically three times a day for 11 to 14 days in the eyes of rabbits after they had sustained central corneal wounds. In eight of nine rabbits, corneal wound tensile strength was significantly less in BAPN-treated eyes as compared to controls. This finding has important implications in all areas of ocular surgery and injury for control of collagen maturation and its complications in healing.