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Related Experiment Videos

Posture and the composition of plasma.

M Dixon, C R Paterson

    Clinical Chemistry
    |May 1, 1978
    PubMed
    Summary

    Posture significantly impacts plasma concentrations of proteins and protein-bound substances like albumin and cholesterol in healthy individuals. These postural variations require careful consideration, especially when precise plasma values are critical for patient monitoring.

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    Area of Science:

    • Clinical Biochemistry
    • Human Physiology

    Background:

    • Plasma constituent concentrations can be influenced by physiological factors.
    • Understanding these variations is crucial for accurate medical interpretation.

    Purpose of the Study:

    • To investigate the effect of posture on plasma levels of various biochemical markers in healthy subjects.
    • To determine the clinical implications of postural changes on blood test results.

    Main Methods:

    • A group of normal medical students participated in the study.
    • Plasma samples were analyzed for total protein, albumin, calcium, alkaline phosphatase, bilirubin, and cholesterol.
    • Measurements were taken in different postural positions (e.g., standing vs. seated).

    Main Results:

    • Standing led to a significant increase in plasma total protein, albumin, calcium, alkaline phosphatase, bilirubin, and cholesterol.
    • These affected substances are primarily proteins or are bound to proteins.
    • Postural effects on calcium can be partially corrected, but protein concentration changes are uncorrectable.

    Conclusions:

    • Posture significantly alters the concentration of several key plasma constituents.
    • Clinicians must account for postural variations when interpreting plasma test results.
    • Care is essential in managing patients, particularly those with conditions like nephrotic syndrome, where precise protein levels are vital.

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