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Fatal intoxication by 1,2-dichloroethane--a case report
International Archives of Occupational and Environmental Health
|January 1, 1984
Summary
Accidental exposure to 1,2-dichloroethane caused acute fatal intoxication. Key findings included elevated lactate, ammonia, and specific liver enzymes before other markers, indicating rapid toxic effects.
Area of Science:
- Toxicology
- Clinical Chemistry
- Pathology
Background:
- Acute fatal intoxication from 1,2-dichloroethane (EDC) exposure is rare.
- Understanding the temporal sequence of biochemical changes is crucial for diagnosis and treatment.
Observation:
- A case report details a 51-year-old male with accidental 1,2-dichloroethane exposure.
- Clinical symptoms, blood chemistry, and autopsy results were systematically documented.
Findings:
- Elevated blood lactate and ammonia levels preceded increases in glutamic transaminases, lactic dehydrogenase, and creatine phosphokinase.
- Remarkably high levels of ornithine carbamyl transferase and mitochondrial glutamic oxaloacetic transaminase (m-GOT) were observed.
Implications:
- This case highlights the rapid and severe toxic effects of 1,2-dichloroethane.
- The specific biochemical markers and their temporal sequence may aid in diagnosing and managing similar poisoning incidents.