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Related Experiment Videos

[Side effects and risks of phototherapy].

H Pullmann

    Zeitschrift Fur Hautkrankheiten
    |August 15, 1984
    PubMed
    Summary

    Visible and infrared light from UV-therapy sources cause unknown biological effects, including skin heating and erythema. While UV-light causes acute side effects like sunburn, it does not lead to hyperproliferation.

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    Area of Science:

    • Dermatology and photobiology.
    • Investigating the biological effects of electromagnetic radiation.

    Context:

    • UV-therapy devices emit visible and infrared wavelengths alongside UV light.
    • The biological activities of these non-UV wavelengths are largely unknown.
    • These wavelengths constitute the main energy output of UV sources.

    Purpose:

    • To elucidate the biological activities of visible and ultra-red wavelengths emitted by UV-therapy sources.
    • To differentiate the effects of non-UV wavelengths from direct UV radiation.
    • To understand the acute side effects and cellular responses associated with UV-therapy.

    Summary:

    • Visible and ultra-red wavelengths increase skin surface temperature to 42-44°C, inducing reticulate erythema and basal cell proliferation.
    • This proliferative response mirrors that of SUP (short-wave ultraviolet) or UVA but does not result in hyperproliferation.
    • Acute side effects are primarily toxic reactions to UV light, including sunburn and bullous reactions without scarring.
    • UV-therapy can exacerbate photosensitive dermatoses and internal diseases, and modulate the immune system.

    Impact:

    • Highlights the need to understand the full spectrum of light emitted by UV-therapy devices.
    • Clarifies that non-UV components contribute to immediate skin reactions.
    • Provides insights into the mechanisms of UV-induced skin damage and side effects.
    • Informs clinical practice regarding potential risks and benefits of UV-therapy.

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