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Effects of solvent medium on solubility III: Hydrophilic-lipophilic character exhibited by some functional groups

R H Manzo, A A Ahumada, E Luna

Journal of Pharmaceutical Sciences

|August 1, 1984

Abstract:

Solubility data of nine derivatives of the structure p-X1-C6H4-X2 in ethanol-water at 25 degrees C are reported. The correlation of such sets of data by log Sy = Py X log Sx + C yields the medium effect parameter Py for a variety of functional groups possessing either oxygen or nitrogen. Py accounts for the hydrophilic-lipophilic character exhibited by each group.

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