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Sisomicin: in vitro activity and pharmacokinetics
International Journal of Clinical Pharmacology and Biopharmacy
|April 1, 1978
Summary
Sisomicin demonstrated superior in vitro activity against select Gram-negative bacteria compared to gentamicin. Both antibiotics showed similar pharmacokinetic profiles in healthy volunteers, suggesting comparable efficacy and safety.
Area of Science:
- Microbiology
- Pharmacology
- Clinical Research
Background:
- Aminoglycoside antibiotics like sisomicin and gentamicin are crucial for treating bacterial infections.
- Understanding comparative efficacy and pharmacokinetic profiles is essential for optimal clinical use.
Purpose of the Study:
- To compare the in vitro antibacterial activity of sisomicin and gentamicin.
- To evaluate the pharmacokinetic properties of sisomicin and gentamicin in healthy adult volunteers.
Main Methods:
- In vitro: Serial dilution tests were performed on 619 bacterial strains.
- In vivo: Serum and urine levels were measured after intramuscular injection and continuous intravenous infusion in healthy volunteers.
Main Results:
- Sisomicin exhibited lower minimum inhibitory concentrations (MICs) than gentamicin against Pseudomonas, Proteus vulgaris, Klebsiella, and Serratia.
- Lower resistance rates were observed with sisomicin (2%) compared to gentamicin (8%) in Pseudomonas strains.
- Both antibiotics displayed similar biological half-lives, urine recovery, and renal clearance, with sisomicin showing slightly higher total clearance.
Conclusions:
- Sisomicin shows enhanced in vitro activity against certain Gram-negative bacteria compared to gentamicin.
- Sisomicin and gentamicin exhibit comparable pharmacokinetic profiles, suggesting similar safety and efficacy in vivo.