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Eosinophilic pustular folliculitis in infancy
Abstract:
Five infants under 1 year of age were reported with a syndrome of recurrent crops of pruritic papulopustules of the scalp. In three children there were also intermittent outbreaks on the trunk and extremities. Cultures showed the pustules to be sterile. Biopsies of scalp and skin tissues showed eosinophilic folliculitis. Some patients had eosinophilia during outbreaks of pustules. These cases are similar to the eosinophilic pustular folliculitis reported in a few adult patients with the exception that there was predominant scalp involvement in the children. We propose that eosinophilic pustular folliculitis of infancy is a distinct pustular dermatosis.
Insights
Infants can develop a distinct skin condition called eosinophilic pustular folliculitis, characterized by itchy, sterile pustules primarily on the scalp. This condition may also affect the trunk and extremities, presenting a unique pediatric dermatosis.
Area of Science:
- Pediatric Dermatology
- Dermatopathology
Background:
- Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin condition typically observed in adult patients.
- Previous literature primarily describes scalp and trunk involvement in adult EPF.
Observation:
- Five infants under one year of age presented with recurrent, pruritic papulopustules predominantly affecting the scalp.
- Three infants also experienced intermittent pustular outbreaks on the trunk and extremities.
- Microbiological cultures of pustules were sterile.
Findings:
- Skin and scalp biopsies revealed eosinophilic folliculitis.
- Peripheral eosinophilia was noted in some patients during pustular outbreaks.
- The clinical presentation in infants differed from adult EPF due to predominant scalp involvement.
Implications:
- The findings suggest a distinct pediatric variant of eosinophilic pustular folliculitis.
- This condition represents a unique pustular dermatosis in infancy.
- Further research is warranted to understand the pathogenesis and long-term outcomes of infantile EPF.