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Related Experiment Videos

Selection effects of repeatability criteria applied to lung spirometry.

E A Eisen, J M Robins, I A Greaves

    American Journal of Epidemiology
    |November 1, 1984
    PubMed
    Summary

    Excluding individuals with nonrepeatable pulmonary function tests may bias research. Studies show these individuals often have faster lung function decline, suggesting exclusion can skew epidemiologic findings.

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    Area of Science:

    • Occupational Health
    • Pulmonary Medicine
    • Epidemiology

    Background:

    • Excluding subjects with nonrepeatable pulmonary function tests is common practice in research.
    • This exclusion may introduce bias into studies examining lung function decline.

    Purpose of the Study:

    • To investigate the potential for bias introduced by excluding subjects with nonrepeatable pulmonary function measurements.
    • To assess the lung function loss rate in subjects with persistent test failures compared to those without.

    Main Methods:

    • A five-year cohort study of Vermont granite workers was conducted.
    • Nonrepeatable measurements were defined by specific criteria for forced expiratory volume in one second (FEV1).
    • Persistent test failure was analyzed based on the frequency and magnitude of measurement discrepancies.

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    Main Results:

    • Subjects with persistent test failures exhibited a faster rate of FEV1 loss.
    • Exclusion based on rigid repeatability criteria may disproportionately remove subjects with accelerated lung function decline.

    Conclusions:

    • Rigid repeatability criteria in pulmonary function testing can introduce bias into epidemiologic studies.
    • Excluding subjects with nonrepeatable tests may obscure important findings regarding lung function decline and occupational exposures.