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Multiple primary cancers in Singapore 1968-1978
Annals of the Academy of Medicine, Singapore
|April 1, 1984
Summary
This study analyzed 121 multiple primary cancer cases in Singapore from 1968-1978. Strict registration criteria resulted in a low incidence, with females diagnosed younger and specific site associations noted.
Area of Science:
- Oncology
- Epidemiology
- Cancer Registry Studies
Background:
- The Singapore Cancer Registry employs stringent criteria for registering multiple primary cancers.
- This analysis focuses on cases identified between 1968 and 1978.
Purpose of the Study:
- To report on the incidence and characteristics of multiple primary cancers under strict registration criteria.
- To identify demographic and temporal patterns in patients with multiple primary cancers.
Main Methods:
- Retrospective analysis of 121 registered cases of multiple primary cancers.
- Inclusion criteria excluded second primaries in multicentric foci within the same or paired organs.
- Data collected on patient demographics, diagnosis intervals, and cancer site associations.
Main Results:
- Multiple primary cancers represented 0.5% of all registered cancer cases.
- Females were more frequently diagnosed with multiple primary cancers than males.
- Females were diagnosed at a younger mean age (54 years) compared to males (60 years).
- The median time interval between diagnoses was 3 years, longer in younger patients.
- Observed site associations included kidney-bladder and cervix-lung combinations.
Conclusions:
- Strict registration criteria significantly limit the reported incidence of multiple primary cancers.
- Demographic differences, particularly in age at diagnosis between sexes, are evident.
- Specific cancer site combinations warrant further investigation for potential etiological links.