Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital malformations, mortality and styrene exposure.

H Härkönen, S Tola, M L Korkala

    Annals of the Academy of Medicine, Singapore
    |April 1, 1984
    PubMed
    Summary

    This study found no increased risk of congenital malformations in children born to styrene-exposed workers. Worker mortality and cancer rates were also lower than expected, despite some cancers appearing early in exposure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Can fifth nerve mapping guide rhizotomy for recurrent trigeminal neuralgia? Case report.

    Neuro-Chirurgie·2022
    Same author

    Comparative characterisation of human and ovine non-<i>aureus</i> staphylococci isolated in Sardinia (Italy) for antimicrobial susceptibility profiles and resistance genes.

    Epidemiology and infection·2021
    Same author

    Biofilm formation and virulence factor analysis of Staphylococcus aureus isolates collected from ovine mastitis.

    Journal of applied microbiology·2017
    Same author

    Hemilaminectomy for spinal meningioma: A case series of 20 patients with a focus on ventral- and ventrolateral lesions.

    Clinical neurology and neurosurgery·2016
    Same author

    Development of a specific immunomagnetic capture-PCR for rapid detection of viable Mycoplasma agalactiae in sheep milk samples.

    Journal of applied microbiology·2014
    Same author

    Proteomic approach for identification of immunogenic proteins of Mycoplasma mycoides subsp. capri.

    Veterinary microbiology·2013

    Area of Science:

    • Occupational Health
    • Reproductive Toxicology
    • Epidemiology

    Background:

    • Styrene exposure is common in reinforced plastic manufacturing.
    • Concerns exist regarding potential reproductive and long-term health effects of styrene exposure.

    Purpose of the Study:

    • To investigate the prevalence of congenital malformations in offspring of styrene-exposed workers.
    • To assess the mortality rates, including cancer incidence, among styrene-exposed workers.

    Main Methods:

    • A cohort of 2,209 workers (1,698 men, 511 women) from 160 workplaces manufacturing reinforced plastic products was studied.
    • Worker exposure histories dated back to 1960, with most exposure after 1967.
    • Data on children's congenital malformations were linked with a national register; worker mortality was tracked.

    Main Results:

    • The incidence of congenital malformations in children born to exposed workers was below expected values, both before and during parental styrene exposure.
    • The cohort experienced 37 observed deaths, significantly lower than the expected 74.0.
    • Six cancer deaths were observed (expected 13.0), with specific sites including stomach, bronchus, breast, ovary, and kidney. No lymphatic or hematopoietic cancers were found.
    • Most observed cancers occurred after short exposure durations and relatively soon after exposure began.

    Conclusions:

    • Styrene exposure in this cohort did not appear to increase the risk of congenital malformations in offspring.
    • Overall worker mortality and cancer incidence were lower than expected, suggesting a potential healthy worker effect or other confounding factors.
    • The observed cancer patterns warrant further investigation, particularly the timing relative to exposure onset.

    Related Experiment Videos