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Pemphigus foliaceus induced by rifampicin
The British Journal of Dermatology
|November 1, 1984
Summary
Rifampicin therapy for tuberculosis can cause pemphigus foliaceus, a skin condition. Discontinuing the drug led to complete resolution of the lesions without further treatment.
Area of Science:
- Dermatology
- Infectious Diseases
- Pharmacology
Background:
- Pulmonary tuberculosis is a common infectious disease.
- Rifampicin is a key antibiotic used in tuberculosis treatment.
- Drug-induced dermatological reactions can complicate treatment regimens.
Observation:
- A patient undergoing rifampicin therapy for pulmonary tuberculosis developed pemphigus foliaceus.
- The patient presented with eczematoid patches, flaccid bullae, and crusted plaques.
- Histological examination revealed suprabasal epidermal blisters with acantholysis.
Findings:
- Immunofluorescence studies confirmed the diagnosis of pemphigus foliaceus.
- Cessation of rifampicin therapy resulted in complete clearance of skin lesions within 5 weeks.
- No additional systemic medication was required for dermatological treatment.
Implications:
- Rifampicin should be considered as a potential cause of pemphigus foliaceus in patients with tuberculosis.
- Early recognition and drug withdrawal can effectively manage this adverse reaction.
- This case highlights the importance of monitoring for cutaneous side effects during antibiotic therapy.