[Kinetics of benzo[a]pyrene penetration into the mouse skin after treatment with various phenols]

A mathematical method for the study of benzo(a)pyrene (BP) penetration into the skin of nude mice was elaborated and supported by the experimental data. BP, whose concentration was measured by its fluorescence intensity, was applied to the skin using a "dry" technique. The effect of certain phenols and products of oxybenzene oxidation was studied. It was found that only butylated hydroxytoluene inhibits essentially the rate of BP metabolism.