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[The measurement of dializable free testosterone]
Nihon Naibunpi Gakkai Zasshi
|July 20, 1984
Summary
Free testosterone (FT) is the active form of testosterone in the blood. This study measured dializable free testosterone (AFT) in various conditions, finding significant differences in FT levels across normal males, females, pregnancy, and hypogonadism.
Area of Science:
- Endocrinology
- Andrology
- Clinical Chemistry
Context:
- Non-protein bound testosterone, or free testosterone (FT), is biologically active.
- Measuring dializable free testosterone (AFT) provides insight into androgenicity.
- FT levels vary significantly between sexes and physiological states.
Purpose:
- To measure dializable free testosterone (AFT) in various endocrine and metabolic disorders.
- To compare AFT levels in normal males and females, pregnancy, hypogonadism, chronic hepatitis, and hyperthyroidism.
- To assess the relationship between total testosterone (T), fractional free testosterone (%FT), and AFT in different clinical conditions.
Summary:
- Normal males had significantly higher plasma testosterone (T), fractional free testosterone (%FT), and AFT compared to normal females and pregnant women.
- Both primary and secondary hypogonadism in males showed significantly decreased T and AFT levels.
- In chronic hepatitis and hyperthyroidism, total testosterone (T) was elevated, but %FT was decreased, with AFT levels comparable to normal males.
Impact:
- Establishes reference ranges for AFT in different populations and conditions.
- Highlights the importance of assessing free testosterone, not just total testosterone, in diagnosing hormonal imbalances.
- Provides data crucial for understanding androgen status in various pathological states, aiding clinical diagnosis and management.