Modulation of nonglobin mRNA levels in erythropoiesis

During erythropoiesis, the decrease of complexity of a RNA population is an important process as is globin mRNA accumulation. To determine the sequential control process of gene expression, many genomic clones which express in mouse reticulocytes were obtained and used for the titration of each mRNA level in the different stages of erythroid cells. The level of mRNAs of rt-clones decreases depending on the maturation of erythroid cells, and the coordinated and sequential control of this level is likely to be one of the factors affecting this process.