Inhibitory effect of tumour cells on leukocyte motility

Hep-2 cells inhibit the random migration of human polymorphonuclear leukocytes in a tumour cell-leukocyte microenvironmental model, which is a special form of co-migration. The inhibition is indomethacin-sensitive. It is very likely that prostaglandins, produced as a consequence of interaction between tumour cells and leukocytes, are the mediators of this phenomenon. The tumour-induced inhibition of leukocyte motility may represent a tumour-protective mechanism.