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Destruction of acetylcholine receptor by decaying 125I-alpha-bungarotoxin
The Journal of Biological Chemistry
|November 25, 1984
Abstract:
Decay of 125I in 125I-alpha-bungarotoxin bound to detergent-solubilized acetylcholine receptor from Torpedo californica electric tissue results in the inactivation of virtually all of the directly occupied and of the second toxin-binding sites. This finding establishes the usefulness of 125I-labeled ligands for binding-site multiplicity analysis of proteins.