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Dietary carcinogens and anti-carcinogens
Journal of Toxicology. Clinical Toxicology
|January 1, 1984
Summary
New scientific methods help understand cancer and aging-related diseases caused by environmental carcinogens and oxygen radicals. Risk quantification is crucial, though extrapolating animal data to humans remains challenging.
Area of Science:
- Environmental Health
- Toxicology
- Gerontology
Background:
- Emerging methodologies enhance the scientific understanding of cancer and degenerative diseases.
- Environmental and occupational carcinogens and anticarcinogens are key areas of study.
- Natural mutagens and carcinogens in food, along with oxygen radicals, are implicated in disease.
Purpose of the Study:
- To review powerful new methodologies for assessing environmental and occupational carcinogens.
- To relate these tools to natural food mutagens/carcinogens and oxygen radicals in aging.
- To discuss risk quantification and the challenges of extrapolating animal data to humans.
Main Methods:
- Review of novel methodologies for carcinogen and anticarcinogen assessment.
- Analysis of data on natural mutagens, carcinogens, and oxygen radicals.
- Discussion of risk quantification strategies and interspecies extrapolation challenges.
Main Results:
- New tools provide powerful approaches to studying carcinogens and anticarcinogens.
- Oxygen radicals are identified as a cause of aging-associated degenerative disease.
- Significant variability in carcinogen/anticarcinogen potency necessitates careful risk assessment.
Conclusions:
- Understanding carcinogens and degenerative disease requires advanced methodologies.
- Quantifying risks from environmental and dietary factors is essential for public health.
- Despite challenges, improved understanding contributes to rising life expectancy.