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Related Experiment Videos

Echocardiography in sarcoidosis.

P Gregor, P Widimsky, T Sladkova

    Japanese Heart Journal
    |July 1, 1984
    PubMed
    Summary

    Echocardiography revealed mitral valve prolapse in nearly half of lung sarcoidosis patients. Corticosteroids did not alter echocardiographic findings, but improved arrhythmias in some patients.

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    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2014

    Area of Science:

    • Cardiology
    • Pulmonology
    • Medical Imaging

    Background:

    • Sarcoidosis is a multisystem inflammatory disease that can affect the heart.
    • Cardiac involvement in sarcoidosis can lead to various cardiovascular complications.
    • Echocardiography is a key non-invasive tool for assessing cardiac structure and function.

    Purpose of the Study:

    • To evaluate cardiac abnormalities in patients with biopsy-proven lung sarcoidosis using echocardiography.
    • To investigate the prevalence of mitral valve prolapse, pericardial effusion, and septal abnormalities.
    • To assess the impact of corticosteroid treatment on echocardiographic findings and patient symptoms.

    Main Methods:

    • A cohort of 39 patients with biopsy-proven lung sarcoidosis underwent comprehensive echocardiographic examinations.
    • One-dimensional, two-dimensional, and pulsed Doppler echocardiography were utilized.
    • Echocardiographic parameters including mitral valve morphology, pericardial effusion, and interventricular septum function were analyzed.

    Main Results:

    • Mitral valve prolapse was identified in 18 patients (46.2%), potentially explaining symptoms like palpitations and chest pain.
    • A minor pericardial effusion was present in 8 patients (20.5%).
    • Reduced systolic thickening and excursions of the interventricular septum were observed in 4 patients (10.2%), possibly due to granulomatous infiltration. Asymmetric septal hypertrophy was also noted in 4 patients (10.2%).
    • Corticosteroid therapy did not significantly alter echocardiographic findings or pericardial effusion volume.
    • However, corticosteroid treatment led to the disappearance of extrasystoles and subjective relief in patients experiencing palpitations and arrhythmias.

    Conclusions:

    • Echocardiography is valuable in detecting cardiac abnormalities in lung sarcoidosis patients, notably mitral valve prolapse.
    • While corticosteroids may not modify structural cardiac changes, they can alleviate arrhythmic symptoms in sarcoidosis patients.
    • Further research is warranted to understand the long-term cardiac implications of sarcoidosis and optimize management strategies.

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