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Myeloproliferative disease in a cat.
Modern Veterinary Practice
|October 1, 1984
Summary
Myeloproliferative disease is rare in cats, but a case in a Siamese feline showed severe anemia and blast cells. Despite treatment, the cat succumbed to the aggressive bone marrow disorder.
Area of Science:
- Veterinary Medicine
- Hematology
- Oncology
Background:
- Myeloproliferative disorders are bone marrow abnormalities that are uncommon in domestic animals, particularly cats.
- These conditions involve the uncontrolled proliferation of myeloid cells.
Observation:
- A 4-year-old female Siamese cat presented with splenomegaly, weight loss, listlessness, anorexia, pallor, and dehydration.
- Initial hemogram revealed severe macrocytic normochromic anemia, leukocytosis, reticulocytosis, nucleated red blood cells, and undifferentiated blast cells.
- Bone marrow examination showed a predominance of undifferentiated blast cells, red blood cell precursors, and myeloblasts.
Findings:
- The feline leukemia virus (FeLV) test was positive.
- Despite blood transfusion and chemotherapy, the cat died 66 days after diagnosis.
- Necropsy confirmed myeloproliferative disease with significant hepatic and splenic invasion.
Implications:
- This case highlights the aggressive nature of myeloproliferative disease in cats, even with treatment.
- Early diagnosis and understanding the clinical presentation are crucial for managing feline myeloproliferative disorders.
- FeLV infection may play a role in the pathogenesis of myeloproliferative disease in susceptible felines.