[Effects of clindamycin and josamycin in experimental Toxoplasma gondii infections]

The effects of clindamycin and josamycin on experimental toxoplasmosis of mice (RH strain) are studied. Oral administration of clindamycin 800 mg/kg daily for 14 days cured 80% of Toxoplasma-infected mice at 60 days after infection. Josamycin, administered subcutaneously at 100, 200, 500, 1000 mg/kg daily for 14 days did not prevent death due to acute infection, and no difference was demonstrated with untreated infected mice.