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Safe common agents for improved NMR contrast.
Physiological Chemistry and Physics and Medical NMR
|January 1, 1984
Summary
Common agents like olive oil and ethanol can alter Nuclear Magnetic Resonance (NMR) imaging contrast. This study measured their effects on T1 and T2 relaxation times in various tissues, showing potential for clinical applications.
Area of Science:
- Medical Imaging
- Biophysics
Background:
- Nuclear Magnetic Resonance (NMR) imaging requires agents to enhance natural tissue relaxation time differences.
- Contrast agents that reflect tissue physiology and disease are highly valuable for improved diagnostics.
Purpose of the Study:
- To evaluate common, non-specialized agents for their ability to alter NMR contrast.
- To present measurements of the effects of these agents on T1 and T2 relaxation times in various human tissues.
Main Methods:
- Investigated the effects of olive oil, estrogen hormones, diuretics, ethanol, glycerin, and dimethyl sulfoxide on NMR relaxation times.
- Measured T1 and T2 relaxation times in normal and cancerous breast tissues, other body organs, and brain tissue.
Main Results:
- Several common agents, including olive oil and ethanol, were found to alter NMR contrast.
- Relative effects on T1 and T2 relaxation times were quantified for different tissues.
Conclusions:
- Commonly available agents can modify NMR imaging contrast.
- These agents may offer immediate practical applications in human NMR imaging studies.