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Updated: Aug 5, 2026
07:56
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Summary
Patients with intracranial lesions show significantly higher rates of myocardial damage. This cardiac injury, linked to increased intracranial pressure, may stem from elevated plasma catecholamines.
Area of Science:
- Neuropathology
- Cardiovascular Pathology
- Histochemistry
Background:
- Intracranial lesions can affect systemic physiology.
- Myocardial damage is a potential complication.
- Histochemical methods can detect cellular changes.
Purpose of the Study:
- To compare myocardial damage in patients with intracranial lesions versus controls.
- To investigate the timing and characteristics of focal myocardial damage.
- To explore the relationship between intracranial pressure and cardiac pathology.
Main Methods:
- Autopsy examination of 58 patients with intracranial lesions and 50 controls.
- Histochemical staining for succinic dehydrogenase to assess myocardial damage.
- Correlation of cardiac findings with lesion type, intracranial pressure, and time of death.
Main Results:
- Significantly higher incidence of myocardial damage (62%) in patients with intracranial lesions compared to controls (26%).
- Focal myocardial damage developed after six hours, was not seen after two weeks, and was associated with rapid increases in intracranial pressure.
- Similar myocardial changes observed in control patients with shock or circulatory failure.
Conclusions:
- Rapidly increasing intracranial pressure, potentially via elevated plasma catecholamines, is implicated in focal myocardial damage.
- The observed cardiac lesions are distinct from those in sudden violent deaths.
- Cerebral pathology type influences the development of associated myocardial damage.
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