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The rare red cell phenotype Lan negative in Japanese
Transfusion
|November 1, 1984
Summary
Researchers identified the rare Lan-negative blood group phenotype in three Japanese individuals, marking the first documented cases. Family studies revealed potential genetic links, with no other Lan-negative donors found in extensive screening.
Area of Science:
- Immunology
- Genetics
- Hematology
Background:
- The Lan blood group system is a complex human red blood cell antigen system.
- The Lan-negative phenotype is extremely rare globally, with limited documented cases.
Observation:
- Three Japanese individuals, including two patients and one blood donor, were identified as Lan-negative.
- These individuals also possessed anti-Lan antibodies in their serum.
- Family studies indicated consanguinity in two cases and a Lan-negative sibling in one.
Findings:
- This study reports the first three cases of the Lan-negative phenotype in the Japanese population.
- Extensive screening of 15,000 Japanese blood donors did not reveal any additional Lan-negative individuals.
- The presence of anti-Lan antibodies in identified individuals suggests an immune response to the antigen.
Implications:
- These findings expand the known geographical distribution of the Lan-negative phenotype.
- Understanding the genetic basis and prevalence of rare blood types is crucial for transfusion medicine.
- Further research is needed to characterize the immunogenicity and clinical significance of anti-Lan antibodies.
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