Prevalence of angiographically recognizable atherosclerosis in non-dominant right coronary arteries
Insights
Patients with a non-dominant right coronary artery (NDRCA) show significantly lower rates of obstructive coronary artery disease (CAD) compared to those with a dominant right coronary artery (DRCA). This finding highlights a potential protective factor in NDRCA anatomy.
Area of Science:
- Cardiology
- Vascular Biology
- Medical Imaging
Background:
- Coronary artery dominance describes the vessel supplying the inferior wall of the left ventricle.
- The right coronary artery (RCA) is dominant in approximately 85% of individuals.
Purpose of the Study:
- To investigate the association between right coronary artery (RCA) dominance and the prevalence and severity of coronary artery disease (CAD).
Main Methods:
- Retrospective analysis of 1,000 patients undergoing coronary arteriography.
- Comparison of 89 patients with non-dominant right coronary artery (NDRCA) against 89 matched patients with dominant right coronary artery (DRCA).
- Assessment of obstructive disease and overall coronary disease incidence.
Main Results:
- Lower incidence of obstructive disease in NDRCA (26%) versus DRCA (62%).
- Lower overall coronary disease incidence in NDRCA (56%) versus DRCA (76%).
- Even in patients with CAD, obstructive disease in the RCA was less frequent in NDRCA (46%) than DRCA (80%).
Conclusions:
- Non-dominant right coronary artery anatomy is associated with a reduced prevalence of obstructive coronary artery disease.
- NDRCA may represent a protective anatomical variant against the development of significant coronary atherosclerosis.
Abstract:
Among 1,000 consecutive patients referred for coronary arteriography because of chest pain, 89 patients were found to have a non-dominant right coronary artery (NDRCA). These patients were compared to 89 consecutive patients with dominant right coronary artery (DRCA) matched for age, sex, smoking and serum cholesterol. There was a lower incidence of obstructive disease in NDRCA (23 of 89 patients, 26%) than in DRCA (55 of 89 patients, 62%), X2 = 23.368, p less than 0.001. The incidence of coronary disease was also lower in the NDRCA group, 50 of 89 patients (56%), than in the DRCA group, 68 of 89 patients (76%), X2 = 8.146, p less than 0.01. When only patients with coronary artery disease (CAD) were included in the analysis: 23 of 50 (46%) patients with CAD and NDRCA had obstructive disease in the right coronary artery (RCA) while 55 of 68 (80%) patients with DRCA and CAD had obstructive disease in the RCA, X2 = 15.646, p less than 0.001. The lower incidence of disease in NDRCA persisted even when only the proximal one-third of the DRCA was considered: 41 of 89 (46%) patients with DRCA had proximal lesions compared to the total length of NDRCA, 23 of 89 patients (26%), X2 = 7.940, p less than 0.01.(ABSTRACT TRUNCATED AT 250 WORDS)
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