Perinatal cerebral infarction

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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

L R Ment, C C Duncan, R A Ehrenkranz

    Annals of Neurology
    |November 1, 1984
    PubMed

    Insights

    Perinatal cerebral infarction, or infant stroke, is often diagnosed postmortem. This study found perinatal asphyxia to be a common cause, with most affected infants experiencing poor outcomes.

    Area of Science:

    • Neonatal Neurology
    • Pediatric Stroke
    • Perinatal Medicine

    Background:

    • Perinatal cerebral infarction diagnosis is challenging, often confirmed postmortem.
    • Few studies report on infant survival after perinatal stroke.
    • Neonatal seizures are a common clinical sign.

    Purpose of the Study:

    • To evaluate the incidence and outcomes of perinatal cerebral infarction in infants.
    • To identify common causes and clinical presentations of infant stroke.
    • To assess the short-term prognosis for infants diagnosed with perinatal cerebral infarction.

    Main Methods:

    • Retrospective review of 18 infants diagnosed with perinatal cerebral infarction over a 12-month period.
    • Analysis of clinical data, including gestational age, associated conditions (e.g., intraventricular hemorrhage), and stroke etiology.
    • Correlation of computed tomographic (CT) scan findings with clinical presentation and outcomes.

    Main Results:

    • Eighteen infants with perinatal cerebral infarction were identified.
    • Perinatal asphyxia was the most frequent cause identified.
    • Seven infants were preterm, and 11 were term neonates.
    • Fourteen infants presented with neonatal seizures.
    • Poor outcomes (death or significant disability) were observed in 14 of 18 infants by 4-12 months corrected age.

    Conclusions:

    • Perinatal cerebral infarction is a significant cause of morbidity and mortality in neonates.
    • Perinatal asphyxia is a primary risk factor for infant stroke.
    • Early diagnosis and intervention are crucial, though outcomes remain poor for many affected infants.

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