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Amiodarone photosensitivity.

J F Walter, H Bradner, G P Curtis

    Archives of Dermatology
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Amiodarone hydrochloride can cause skin photosensitivity and corneal deposits. This phototoxic reaction is triggered by UV-A light and lessens after discontinuing the drug.

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    Area of Science:

    • Dermatology
    • Ophthalmology
    • Pharmacology

    Background:

    • Amiodarone hydrochloride is an antiarrhythmic agent investigated in the U.S.
    • European reports suggest amiodarone can cause photosensitivity and skin discoloration.
    • Corneal microdeposits are another potential side effect.

    Observation:

    • A case study details photosensitivity and corneal deposits appearing shortly after amiodarone initiation.
    • Symptoms included immediate burning, stinging, redness, and swelling upon sun exposure.
    • Phototesting identified UV-A wavelengths (350-380 nm) as the primary trigger.

    Findings:

    • A 10% dioxybenzone sunscreen significantly reduced the photosensitivity reaction.
    • UV-A sensitivity persisted for weeks after amiodarone cessation but gradually resolved.

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  • Corneal deposits also reduced in number over time.
  • All ten treated patients exhibited similar photosensitivity, suggesting a phototoxic mechanism.

    • Implications:

    • Amiodarone-induced photosensitivity is likely a phototoxic reaction.
    • Awareness of UV-A sensitivity is crucial for patients on amiodarone.
    • Protective measures, like sunscreen use, can mitigate symptoms.