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Related Experiment Videos

Pulmonary interstitial emphysema.

A Greenough, A K Dixon, N R Roberton

    Archives of Disease in Childhood
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Pulmonary interstitial emphysema in preterm infants is linked to endotracheal tube malposition and high-pressure ventilation. While it increases complications, it does not raise mortality rates.

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    Area of Science:

    • Neonatal Medicine
    • Pediatric Respiratory Medicine
    • Medical Imaging

    Background:

    • Respiratory distress syndrome (RDS) is a common condition in preterm infants.
    • Mechanical ventilation is often required for RDS, but can lead to complications.
    • Pulmonary interstitial emphysema (PIE) is a known complication of mechanical ventilation in neonates.

    Purpose of the Study:

    • To investigate the incidence and risk factors of pulmonary interstitial emphysema (PIE) in preterm infants with RDS.
    • To determine the association between PIE and other complications, including pneumothorax, intraventricular hemorrhage, and mortality.
    • To evaluate the effect of fast rate ventilation on PIE and associated outcomes.

    Main Methods:

    • Retrospective analysis of 210 preterm infants with RDS requiring mechanical ventilation over three years.

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  • Radiological assessment for evidence of PIE.
  • Correlation analysis to identify associations between ventilation parameters, endotracheal tube position, and PIE development and outcomes.

    • Main Results:

    • Forty-one infants (19.5%) developed PIE.
    • PIE was significantly associated with endotracheal tube malpositioning and high peak pressure ventilation.
    • PIE correlated with increased pneumothoraces, intraventricular hemorrhages, and prolonged respiratory support, but not mortality.
    • Fast rate ventilation in 12 infants reduced pneumothoraces but did not alter other outcomes.

    Conclusions:

    • Endotracheal tube malposition and high peak pressure ventilation are significant risk factors for PIE in preterm infants with RDS.
    • PIE is associated with increased morbidity but not mortality.
    • Fast rate ventilation may help reduce pneumothoraces, potentially offering greater benefit if implemented before PIE onset.