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[Hypercalcemia associated with tumors in children. 20 cases]
Archives Francaises De Pediatrie
|October 1, 1984
Summary
Hypercalcemia is common in children with solid tumors, presenting varied symptoms. Anti-tumoral treatment effectively normalizes high calcium levels, unlike emergency interventions.
Area of Science:
- Pediatric Oncology
- Endocrinology
- Nephrology
Context:
- Hypercalcemia is a frequent complication in pediatric oncology.
- Solid tumors, including lymphomas, rhabdomyosarcomas, and Wilms' tumors, are associated with hypercalcemia.
- The clinical presentation and management of hypercalcemia in children with cancer require specific consideration.
Purpose:
- To investigate the occurrence, clinical manifestations, and treatment outcomes of hypercalcemia in children with solid tumors.
- To evaluate the efficacy of different treatment modalities for hypercalcemia in this population.
- To determine the relationship between hypercalcemia and anti-tumoral treatment response.
Summary:
- Thirty episodes of hypercalcemia were documented in 20 pediatric patients with solid tumors.
- Commonly associated tumors included non-Hodgkin's lymphomas, rhabdomyosarcomas, and Wilms' tumors.
- Symptoms ranged from asymptomatic cases to severe neurological manifestations and metastatic calcifications.
- Emergency treatments showed limited efficacy, whereas anti-tumoral therapy consistently normalized calcium levels.
Impact:
- Highlights the importance of monitoring calcium levels in children with solid tumors.
- Suggests that addressing the underlying malignancy is crucial for resolving hypercalcemia.
- Informs clinical practice regarding the management of hypercalcemia in pediatric cancer patients.