Alterations in rat lactate dehydrogenase: age-related comparison of M- and H-LDH
Abstract:
Lactate dehydrogenase (LDH: EC 1.1.1.27) of skeletal muscle and heart was purified from young and old female albino rats. Properties of both types, muscle (M-LDH) and heart (H-LDH), were compared by using enzymes purified from skeletal muscle and hearts of young (22-weeks) and old (116-weeks) rats. M-LDH showed differences with respect to properties such as thermal stability and effects of pH, urea, and sodium sulfite. However, H-LDH did not show any significant alterations in enzyme properties.
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