[Radiomodifying and damaging effect of local hyperthermia on mouse skin depending upon the temperature]

The radiomodifying and damaging effects of heating within the range of 42 degrees-46 degrees C were studied for the skin of random-bred mice. The frequency of development of skin necrosis depends on the time of heating. An increase in temperature by 1 degree C causes a 2-fold decrease in the time-period required for achieving the same effect. A radiosensitizing hyperthermal effect with raising temperature or an increase in the period of heating lessens which may be accounted for by an increased contribution of its damaging effect to the summary effect of radiothermal exposure.