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Liquid and solid potassium chloride: bioavailability and safety.

V A Skoutakis, S R Acchiardo, N J Wojciechowski

    Pharmacotherapy
    |November 1, 1984
    PubMed
    Summary
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    Microencapsulated potassium chloride preparations may be safer for the upper gastrointestinal tract than wax-matrix versions. Current evidence does not definitively show increased gastrointestinal lesions with any specific slow-release potassium chloride formulation.

    Area of Science:

    • Pharmacology and Therapeutics
    • Gastroenterology

    Background:

    • Wax-matrix potassium chloride preparations have been associated with upper gastrointestinal mucosal risks.
    • Microencapsulated potassium chloride formulations are proposed as a potentially safer alternative.

    Purpose of the Study:

    • To evaluate the safety and efficacy of different potassium chloride preparations.
    • To compare the incidence of upper gastrointestinal lesions between microencapsulated and wax-matrix potassium chloride formulations.

    Main Methods:

    • Review of clinical experience and existing literature on potassium chloride preparations.
    • Analysis of data regarding gastrointestinal mucosal safety profiles.

    Main Results:

    • Liquid and slow-release potassium chloride preparations demonstrate safety and efficacy with appropriate use.

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  • No conclusive evidence indicates a higher prevalence of upper gastrointestinal lesions with one slow-release preparation over another.

    • Conclusions:

    • Appropriate use of liquid and slow-release potassium chloride is considered safe and effective.
    • Current data do not support significant differences in upper gastrointestinal lesion prevalence among various slow-release potassium chloride preparations.