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Serum theophylline by fluorescence polarisation immunoassay
Annals of Clinical Biochemistry
|November 1, 1984
Summary
The Abbott TDX system accurately quantifies drug levels in plasma using fluorescence polarization. This easy-to-use system provides rapid, reliable results, with stable reagents reducing calibration frequency despite higher initial costs.
Area of Science:
- Clinical Chemistry
- Analytical Chemistry
- Biotechnology
Background:
- Accurate quantitation of drug levels in plasma is crucial for therapeutic drug monitoring.
- Existing methods may present challenges in terms of speed, ease of use, or calibration frequency.
Purpose of the Study:
- To evaluate the performance of the Abbott TDX system for plasma drug level quantitation.
- To assess the system's ease of use, reliability, and efficiency.
Main Methods:
- Utilizes fluorescence polarization and competitive binding analysis.
- Employs the Abbott TDX system for drug level measurements in plasma samples.
Main Results:
- The Abbott TDX system demonstrated ease of use.
- The system produced reliable and rapid results for drug quantitation.
- Reagent stability allows for infrequent calibration, balancing reagent cost.
Conclusions:
- The Abbott TDX system is a user-friendly and efficient tool for plasma drug monitoring.
- The system offers a reliable method for quantitating drug levels with practical advantages in calibration frequency.