Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exact confidence intervals following a group sequential test.

A A Tsiatis, G L Rosner, C R Mehta

    Biometrics
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Droplet size distribution characteristics of Bacillus thuringiensis and Beauveria bassiana bio-pesticide solutions for hydraulic nozzles.

    Scientific reports·2026
    Same author

    Analyzing Audiometric Data of Agricultural Tractor Drivers in India Using Data Mining Techniques.

    Journal of agromedicine·2026
    Same author

    Optimization of specific spray volume for spray application in pomegranate orchard using response surface methodology.

    Scientific reports·2026
    Same author

    Approach for ergonomic assessment of self-propelled combine harvester seats based on anthropometric body dimensions.

    International journal of occupational safety and ergonomics : JOSE·2022
    Same author

    Application of a sequential multiple assignment randomized trial (SMART) design in older patients with chronic lymphocytic leukemia.

    Annals of oncology : official journal of the European Society for Medical Oncology·2019
    Same author

    An adaptive population enrichment phase III trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma (TAPPAS trial).

    Annals of oncology : official journal of the European Society for Medical Oncology·2018
    Same journal

    Causally-interpretable random-effects meta-analysis.

    Biometrics·2026
    Same journal

    Statistical inference for mean function of partially observed functional time series.

    Biometrics·2026
    Same journal

    Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

    Biometrics·2026
    Same journal

    Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

    Biometrics·2026
    Same journal

    Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

    Biometrics·2026
    Same journal

    A Bayesian phase I/II platform design with data augmentation accounting for delayed outcomes.

    Biometrics·2026
    See all related articles

    A new numerical method provides exact confidence intervals for normal distribution means after group sequential tests. This approach ensures accurate coverage probabilities, outperforming standard methods.

    Area of Science:

    • Statistics
    • Biostatistics

    Background:

    • Group sequential tests are common in clinical trials for early stopping.
    • Traditional confidence intervals may lack exact coverage probabilities in this context.

    Purpose of the Study:

    • To develop and present a numerical method for computing exact confidence intervals.
    • To evaluate the performance of these intervals for the mean of a normal distribution following group sequential testing.

    Main Methods:

    • A numerical method is employed to calculate confidence intervals.
    • The method utilizes a specific ordering of the sample space, drawing inspiration from Siegmund (1978).
    • Comparison is made against the standard confidence interval for the mean.

    Main Results:

    Related Experiment Videos

    • The proposed method yields confidence intervals with exact coverage probabilities.
    • Demonstration of the method's application to normal distribution means.

    Conclusions:

    • The developed numerical method offers a statistically rigorous approach to confidence interval construction.
    • This method provides superior accuracy in coverage probabilities compared to usual confidence intervals in group sequential settings.