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A death from fentanyl overdose.

J C Garriott, R Rodriguez, V J Di Maio

    Journal of Analytical Toxicology
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    A case of fatal fentanyl self-injection is detailed, along with a new detection method for autopsy specimens. This method uses gas chromatography/mass spectrometry to quantify fentanyl in blood, urine, and bile.

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    Area of Science:

    • Forensic toxicology
    • Analytical chemistry
    • Pharmacology

    Background:

    • Fentanyl overdose deaths are a significant public health concern.
    • Accurate postmortem detection of fentanyl is crucial for determining cause of death.
    • Established analytical methods may require optimization for sensitivity and specificity.

    Observation:

    • A case of death attributed to self-injection of fentanyl was investigated.
    • Biological samples (blood, urine, bile) were collected during autopsy.
    • A novel extraction and detection protocol was developed for fentanyl analysis.

    Findings:

    • Fentanyl was successfully extracted from biological matrices using ethyl acetate and acid-base partitioning.
    • Selective ion monitoring gas chromatography/mass spectrometry provided sensitive and specific fentanyl quantification.

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  • Concentrations of 4.8 µg/L in blood, 6.3 µg/L in urine, and 4.7 µg/L in bile were detected.

    • Implications:

    • The reported method offers a reliable approach for detecting fentanyl in postmortem toxicology.
    • This technique can aid forensic pathologists in establishing cause of death in suspected overdose cases.
    • Quantification of fentanyl in various biological fluids enhances understanding of its distribution and elimination in fatal cases.