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Related Experiment Videos

Homology modeling, model and software evaluation: three related resources

R Rodriguez1, G Chinea, N Lopez

  • 1Center for Genetic Engineering and Biotechnology, Havana, Cuba and 2BIOcomputing, EMBL, Heidelberg, Germany.

Bioinformatics (Oxford, England)
|August 8, 1998
PubMed
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Homology modeling generates protein structures from sequences. Three new servers provide tools for creating protein models and evaluating their quality, aiding researchers in structural biology.

Area of Science:

  • Structural biology
  • Computational biology
  • Bioinformatics

Background:

  • Genome projects accelerate protein sequence generation, outpacing experimental structure determination (NMR, X-ray crystallography).
  • Homology modeling is increasingly vital for obtaining protein 3D coordinates.
  • Novice users require support in assessing the quality of protein models.

Purpose of the Study:

  • To provide accessible tools for homology modeling and model quality assessment.
  • To offer a means for evaluating the performance of protein modeling programs.

Main Methods:

  • Development and deployment of three distinct web servers: a homology modeling server, a model quality evaluation server, and a program quality assessment server.
  • These servers are accessible via a web interface.

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Main Results:

  • Three functional servers are now available to the scientific community.
  • The servers facilitate protein model generation, quality evaluation, and implicit assessment of modeling program performance.
  • The tools are freely accessible online.

Conclusions:

  • The developed servers address the growing need for reliable protein structure modeling and quality assessment.
  • These resources support researchers in structural biology and computational chemistry.
  • The availability of these tools enhances the utility of homology modeling in biological research.