[Mesopharynx cancers--multifactorial malignancy analysis and therapeutic results]

Area of Science:

• Oncology
• Pathology

Context:

• Squamous cell carcinoma of the mesopharynx is a significant clinical challenge.
• Accurate diagnosis and prognosis are crucial for effective treatment planning.

Purpose:

• To evaluate a multi-step diagnostic method for mesopharyngeal squamous cell carcinoma.
• To correlate clinicopathological features with prognosis and survival rates.

Summary:

• A multi-step diagnostic approach integrating staging, histological classification, and grading was applied to 210 mesopharyngeal squamous cell carcinomas.
• Extended tumors (T3-T4) were common (61%), with no clear size-prognosis relationship. Regional lymph node metastasis (81%) was associated with a lower cure rate (41%).
• Histological grading (G1-G3) demonstrated a clear prognostic gradient, with G1 showing superior outcomes. Combined surgical and irradiation therapy yielded the highest 5-year survival rate (63%), followed by radical resection (50%), while exclusive irradiation therapy had a lower rate (29%).

Impact:

• The findings highlight the importance of lymph node status and histological grading in predicting outcomes for mesopharyngeal squamous cell carcinoma.
• The study supports combined surgical and irradiation therapy as an effective treatment strategy, improving patient survival rates.