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[Physical exertion tolerance in patients with ischemic heart disease associated with cerebral arteriosclerosis]
Insights
Patients with coronary heart disease (CHD) and cerebral atherosclerosis show reduced exercise tolerance. This occurs because cerebral atherosclerosis worsens the oxygen supply-demand imbalance in the heart during physical activity.
Area of Science:
- Cardiology
- Neurology
- Exercise Physiology
Context:
- Comparative study of exercise tolerance in patients with coronary heart disease (CHD).
- Investigated the impact of co-existing cerebral atherosclerosis on CHD patients.
- Utilized bicycle ergometry testing for assessment.
Purpose:
- To compare exercise tolerance between patients with CHD alone and those with associated CHD and cerebral atherosclerosis.
- To elucidate the mechanisms underlying reduced working capacity in patients with both conditions.
- To determine how cerebral atherosclerosis influences the pathogenetic mechanisms of CHD.
Summary:
- Patients with CHD and cerebral atherosclerosis exhibited lower exercise capacity compared to those with CHD alone.
- Physical loading in patients with both conditions resulted in a less economical circulatory response, marked by increased heart rate and blood pressure.
- Higher myocardial oxygen demand during exercise in the dual-condition group correlated with more frequent ischemic alterations and ST segment depression on ECG.
Impact:
- Concludes that concomitant cerebral atherosclerosis exacerbates the fundamental pathogenetic mechanisms of CHD.
- Highlights the critical imbalance between myocardial oxygen requirement and supply in patients with both diseases.
- Provides insights into the complex interplay between cardiovascular and cerebrovascular diseases during physical stress.
Abstract:
The authors provide the results of a comparative study of exercise tolerance (bicycle ergometry test) in 64 patients with coronary heart disease (CHD) and in 68 patients with associated CHD and cerebral atherosclerosis. During the latter syndrome the working capacity was lowered as a result of less economical work of the circulatory apparatus. In particular, physical loading in such patients was accompanied by marked increment of the heart rate and blood pressure elevation. Increased heart oxygen requirement in the second group patients during exercise was accompanied by more frequent ischemic alterations in the myocardium attended by ST segment depression on the ECG. It is concluded that concomitant cerebral atherosclerosis aggravates the basic pathogenetic mechanisms of CHD, namely the disagreement between myocardium oxygen requirement and supply.