Prostaglandin-inhibitor naproxen does not affect contact lens-induced changes in the human corneal endothelium

A randomized, double-masked, placebo-controlled study was conducted to determine the effect of the prostaglandin-inhibitor naproxen on the bleb response of the corneal endothelium during hydrogel contact lens wear. Naproxen did not significantly alter the bleb response. This finding suggests that the endothelial bleb response is not prostaglandin-mediated.