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Related Experiment Videos

Bioadhesive intraoral release systems: design, testing and analysis.

R Gurny, J M Meyer, N A Peppas

    Biomaterials
    |November 1, 1984
    PubMed
    Summary

    This study optimized polymeric gels for drug delivery. Optimal adhesion and local anesthetic release were achieved using specific sodium carboxymethylcellulose (NaCMC) concentrations in the bioadhesive polymer system.

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    Area of Science:

    • Polymer Science
    • Materials Science
    • Pharmaceutical Sciences

    Background:

    • Bioadhesive polymer systems are crucial for localized drug delivery.
    • Hydrophobic gels require specific formulations to control adhesion and drug release.
    • Sodium carboxymethylcellulose (NaCMC) and hydrolysed gelatin are key components in developing advanced drug delivery systems.

    Purpose of the Study:

    • To analyze the adhesion properties of various polymeric formulations.
    • To measure the in vitro release of febuverine hydrochloride from a hydrophobic gel.
    • To determine the optimal NaCMC content for enhanced bioadhesion and controlled drug release.

    Main Methods:

    • Preparation of polyethylene-based bioadhesive polymer systems with varying NaCMC and hydrolysed gelatin concentrations.
    • Adhesion studies using a tensile tester with a custom-made cell upon hydration.
    • In vitro release studies of febuverine hydrochloride using a dissolution cell with artificial saliva at 37°C.

    Main Results:

    • Relative adhesive bond strength of formulations peaked at approximately 20 wt% NaCMC.
    • Optimal release rates for febuverine hydrochloride were observed in formulations containing 12-25 wt% NaCMC.
    • The NaCMC content significantly influenced both the adhesive properties and drug release kinetics.

    Conclusions:

    • Polymeric formulations containing NaCMC demonstrate tunable bioadhesive properties.
    • The NaCMC concentration is a critical factor in optimizing both adhesion and controlled release of local anesthetics.
    • These findings contribute to the development of effective hydrophobic gel-based drug delivery systems.

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