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Clinical experience with ioxaglate (Hexabrix) in selective coronary arteriography
Journal of the Canadian Association of Radiologists
|December 1, 1984
Summary
This study found that ioxaglate (Hexabrix), a new low osmolality contrast medium, is safe and effective for cardiac catheterization and coronary arteriography. It offers excellent radiographic quality with minimal side effects, making it suitable for high-risk patients.
Area of Science:
- Cardiology
- Radiology
- Pharmacology
Background:
- Contrast media are essential for cardiovascular imaging.
- Low osmolality contrast media aim to improve patient safety and tolerance.
- Ioxaglate is a novel low osmolality contrast medium for angiocardiography.
Purpose of the Study:
- To evaluate the safety, efficacy, and patient tolerance of ioxaglate.
- To assess the radiographic quality of angiograms produced with ioxaglate.
- To determine the suitability of ioxaglate for high-risk cardiovascular patients.
Main Methods:
- Prospective, nonrandomized study.
- 90 adult patients undergoing cardiac catheterization and selective coronary arteriography.
- Evaluation of adverse effects, hemodynamic changes, arrhythmias, and radiographic quality.
Main Results:
- Ioxaglate demonstrated a favorable safety profile with no major adverse effects.
- Side effects were rare and mild; hemodynamic changes were minimal.
- Excellent radiographic quality was achieved, comparable to conventional contrast media.
- No arrhythmias were observed during the procedures.
Conclusions:
- Ioxaglate is a safe and effective contrast medium for angiocardiography.
- It is well-tolerated by patients, including those with severe coronary artery disease or left ventricular dysfunction.
- Ioxaglate is a potential contrast medium of choice for high-risk patients undergoing cardiac procedures.