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Breathing pattern and stretch receptor activity during high frequency ventilation.

J Kohl, E A Koller

    Pflugers Archiv : European Journal of Physiology
    |October 1, 1984
    PubMed
    Summary
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    High frequency ventilation (HFV) in rabbits inhibits breathing by increasing expiratory stretch receptor activity. This HFV effect, unlike lung inflation, preserves phrenic nerve activity, suggesting irritant receptor involvement.

    Area of Science:

    • Physiology
    • Respiratory Mechanics
    • Neuroscience

    Background:

    • High frequency ventilation (HFV) is used clinically, but its respiratory inhibitory mechanisms are not fully understood.
    • Stretch receptors (SR) and irritant receptors play roles in respiratory control.

    Purpose of the Study:

    • To investigate the effects of HFV on breathing patterns and SR activity in rabbits.
    • To elucidate the mechanism of respiratory inhibition during HFV.
    • To compare HFV effects with static lung inflations.

    Main Methods:

    • Anesthetized rabbits were subjected to HFV (5-25 Hz, 5-15 cm H2O peak airway pressure).
    • Breathing patterns, phrenic and diaphragmatic activity were monitored.
    • Stretch receptor activity was recorded during HFV and static lung inflations.

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    Main Results:

    • HFV prolonged expiration and induced apnea, proportional to peak airway pressure.
    • HFV-induced apnea showed persistent phrenic and diaphragmatic activity, unlike static lung inflations.
    • HFV increased expiratory SR discharge rate more than inspiratory SR activity.

    Conclusions:

    • Increased expiratory stretch receptor activity during HFV likely inhibits spontaneous breathing.
    • Persistent phrenic and diaphragmatic activity during HFV-induced apnea may result from irritant receptor activation.